Denver is activating emergency shelters for five days starting Wednesday as cold weather is expected to blanket the region this Thanksgiving weekend.

This week’s emergency shelter operation is the longest so far this year.

The city’s cold weather plan provides additional shelter for people who are not in city shelters or third-party homeless units.

Temperatures in Denver expect to hit the low-to-mid 20s from Wednesday to Monday.

Beginning at 1 p.m. Wednesday, the city will open three shelters at the former Best Western hotel at 4595 Quebec St., and the city facilities at 2601 W. 7th Ave. and 375 S. Zuni St. The former Best Western hotel is now a homeless shelter.

All shelters will close at 11 a.m. pm Monday, according to the city’s housing department.

“Cold weather poses a serious danger to people who are unsheltered,” city officials said.

This is the third occasion this season where the city activated its emergency shelters.

The city last opened emergency shelters on Nov. 19 and three weeks ago during the winter season’s first snowstorm.

Denver offers shelters for specific demographics:

• For individual men: Denver Rescue Mission Lawrence Street Community Center, 2222 Lawrence St.

• For individual women: Samaritan House, 2301 Lawrence St.

• For youth ages 15-20: Urban Peak, 1630 S. Acoma St.

• Families in need of shelter should call the Connection Center at (303) 295-3366.